ZZW-115 NEW
| Price | $182 | $268 | $448 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: ZZW-115 | CAS No.: 801991-87-7 |
| Purity: 99.17% | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | ZZW-115 |
| Description | ZZW-115 is a potent NUPR1 inhibitor with a Kd of 2.1 μM and is a derivative of Trifluoperazine (TFP). It shows dose-dependent tumor regression without neurological side effects and induces cell death mainly by necroptosis and apoptosis[1] [2]. |
| In vitro | ZZW-115, at concentrations ranging from 0.1 to 100 μM and incubation periods between 24 and 72 hours, demonstrates significant anticancer efficacy by effectively killing a variety of cancer cells. It exhibits IC50 values from as low as 0.42 μM in Hep2G cells to 7.75 μM in SaOS-2 cells, indicating its potency across different cell lines including ANOR, HN14, and others [1]. Moreover, ZZW-115 prompts cancer cell death through both necrosis and apoptosis mechanisms, highlighted by increased lactate dehydrogenase (LDH) release and caspase 3/7 activity in treated cells compared to controls. This is further supported by a decrease in ATP production and an overproduction of reactive oxygen species (ROS), showcasing its dual pro-necrotic and pro-apoptotic actions [1]. |
| In vivo | Administering ZZW-115 via injection at doses ranging from 0.5 to 5 mg/kg daily for 30 days inhibited growth in pancreatic xenografted tumors in NMRI-Foxn1nu/Foxn1nu (nude) mice implanted with MiaPaCa-2 cells. At a dosage of 5 mg/kg, ZZW-115 treatment in immunocompetent C57BL/6 mice orthotopically implanted with Panc02 cells resulted in a significant reduction of tumor size, rendering it almost unmeasurable in some instances. Notably, tumors ceased to grow a few days post-administration of 5 mg/kg ZZW-115 and exhibited a progressive decrease in size, nearing complete disappearance by the treatment's conclusion. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | ZZW-115 | ZZW115 | ZZW 115 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $84.00/1mg |
VIP5Y
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TargetMol Chemicals Inc.
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2025-05-26 | |
| $30.00/1mg |
VIP3Y
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TargetMol Chemicals Inc.
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2025-07-14 | |
| $0.00/10mg |
VIP2Y
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ShenZhen H&D Pharmaceutical Technology Co., LTD
|
2024-07-11 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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