Z-LEVD-FMK NEW
| Price | $939 | $1520 |
| Package | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-09 |
Product Details
| Product Name: Z-LEVD-FMK | CAS No.: 1135688-25-3 |
| Supply Ability: 10g | Release date: 2025/05/09 |
Product Introduction
Bioactivity
| Name | Z-LEVD-FMK |
| Description | Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor with potential anticancer activity, capable of eliminating LPS-induced GCLC protein degradation and inducing apoptosis in cancer cells. |
| In vitro | Z-LEVD-FMK is a specific inhibitor of caspase-4. Z-LEVD-FMK (2 μM) completely eliminated IL-8 protein production in induced hRPE cells. [1] Z-LEVD-FMK was most active in blocking 17β-estradiol (E2) -induced apoptosis. In addition, z-LEVD-fmk completely blocked the cutting of ADP-ribose polymerase (PARP), and E2 inhibited growth and apoptotic morphology. [2] Z-LEVD-FMK (50 μM) treated for 72 hours only inhibited IL-17A-induced caspase-4 cleavage and N-terminal GSDMD up-regulation in CRC cells. There was no significant effect on the expression of NLRP3 inflammasome (NLRP3, ASC, caspase-1). [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (153.21 mM), Sonication is recommended. |
| Inhibitors Related | Taurodeoxycholic acid | Allethrin | Crustecdysone | SKLB-163 | Fenbufen | Cystamine | Taurochenodeoxycholic Acid | Tauroursodeoxycholate sodium | (Iso)-Z-VAD(OMe)-FMK | CIL62 | Tauroursodeoxycholate | PAC-1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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