Product Details
| Product Name:
Y16 |
CAS No.:
429653-73-6 |
| Purity:
98.26% |
Supply Ability:
10g |
| Release date:
2025/04/28 |
Product Introduction
Bioactivity
| Name | Y16 |
| Description | Y16 is a G protein-coupled Rho GEFs inhibitor that synergizes with Rhosin/G04 to inhibit LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling. Y16 is also a specific inhibitor of LARG with a Kd of 76 nM. |
| In vitro | METHODS: MCF7 breast cells were treated with Y16 (5, 10, 30, 50 μM), and the effects of Y16 on growth, migration, and invasion, as well as mammosphere formation, breast cancer cell activity, and characteristics related to tumorigenic potential were studied.
RESULTS Y16 significantly inhibited the growth, migration, and invasion of MCF7 breast cancer cells; Y16-treated MCF7 cells also produced smaller size and dose-dependently reduced mammary X-sphere numbers. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mg/mL (26.01 mM), Sonication is recommended.
|
| Keywords | Y-16 | Y16 | Y 16 | Rho GEFs | Ras | Inhibitor | inhibit |
| Inhibitors Related | CCG-257081 | Ketoconazole | SKLB-163 | Deltarasin | ZCL278 | Azathioprine | Salirasib | RMC-6236 | Rhosin hydrochloride | (S)-(-)-Perillyl alcohol | CASIN | Zoledronic Acid |
| Related Compound Libraries | Reprogramming Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Anti-Obesity Compound Library | Inhibitor Library | Anti-Fibrosis Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States