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Postion:Product Catalog >Pharmaceutical intermediates>Heterocyclic compound>Pyridine compound>Ethylpyridine>Y-33075
Y-33075
  • Y-33075

Y-33075 NEW

Price $112 $766 $995
Package 2mg 25mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-26

Product Details

Product Name: Y-33075 CAS No.: 199433-58-4
Supply Ability: 10g Release date: 2025/05/26

Product Introduction

Bioactivity

NameY-33075
DescriptionY-33075 (Y-39983 free base) is a ROCK inhibitor that lowers intraocular pressure (IOP), increases blood flow to the optic nerve head (ONH), and increases the number of RGCs (retinal ganglion cells) in the body with regenerating axons.
In vitroThe in vitro activity of Y-33075 was evaluated in cultured human umbilical vein endothelial cells (HUVECs). After seeding, HUVECs were treated with medium containing Y-33075 (1?μM) for 15 or 30 minutes. The cells exhibited contraction after treatment, but their morphology recovered within 1 hour after the removal of Y-33075. These results indicate that Y-33075 induces endothelial cell contraction, suggesting a potential effect on vascular barrier function [1].
In vivoIn rabbits, a single 50?μL dose of Y-33075 (0.003%–0.1%) reduced IOP by up to 13.2?±?0.6?mmHg (0.1%, 2?h), and repeated dosing (0.03%, 4×/day for 28 days) maintained a 7.0–9.6?mmHg reduction. In monkeys, 0.05% Y-33075 reduced IOP by 2.5?±?0.8?mmHg at 3?h. Y-33075 also enhanced conventional outflow in rabbits (+65.5%), with minimal side effects except occasional subconjunctival hemorrhage at high dosing frequency [2].
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : < 1 mg/mL (insoluble), Sonication is recommended.
DMSO : 40 mg/mL (142.69 mM), Sonication is recommended.
KeywordsY-39983 | Y39983 | Y-33075 | Y 39983 | Y 33075 | ROCK | PKC | CaMKII
Inhibitors RelatedSB-747651A Dihydrochloride | GSK180736A | SAR407899 hydrochloride | RKI-1447 | Belumosudil | Fasudil hydrochloride | Y-27632 dihydrochloride | Y-27632 | ROCK-IN-5 | CID-5056270 | Thiazovivin | CAY10746

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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