Product Details
| Product Name:
VT104 |
CAS No.:
2417718-25-1 |
| Purity:
99.5% |
Supply Ability:
10g |
| Release date:
2025/04/30 |
Product Introduction
Bioactivity
| Name | VT104 |
| Description | VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research. VT104 blocks palmitoylation of endogenous TEAD1 and TEAD3 proteins. |
| In vitro | METHODS: Huh7 cells were treated with the pan-TEAD inhibitor VT104 (0.1, 0.5, 1, 2.5, 5 μM) for 72 h and then subjected to WST assay to assess cell number or 24 h for qPCR of ANKRD1, ANLN, and KIF23.
RESULTS VT104 reduced Huh7 cell proliferation and inhibited the TAZ-TEAD pathway, with reduced expression of TAZ-TEAD targets ANLN, KIF23, ANKRD1, CTGF, and CD274 in Huh7 cells. [3] |
| In vivo | METHODS: Mice after MET+CTNNB1-S45Y HTVI were treated with VT104 (10 mg/kg/day) for 6 weeks.
RESULTS VT104 strongly inhibited HCC development in vivo driven by MET+CTNNB1-S45Y; VT104 significantly reduced Ki67+ proliferation and γH2AX-positive hepatocytes. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (71.36 mM), Sonication is recommended.
|
| Keywords | YAP–TEAD | YAP |
| Inhibitors Related | AICAR | IK-930 | MY-1076 | YAP-TEAD-IN-1 acetate | Verteporfin | YAP-TEAD-IN-3 | DC-TEADin02 | MSC-4106 | VT103 | VT107 | PY-60 | MYF-01-37 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States