Vitamin E Nicotinate

Modify Date: 2024-01-04 10:28:45

Vitamin E Nicotinate structure	Common Name	Vitamin E Nicotinate
	CAS Number	51898-34-1	Molecular Weight	535.800
	Density	1.0±0.1 g/cm3	Boiling Point	649.0±55.0 °C at 760 mmHg
	Molecular Formula	C35H53NO3	Melting Point	N/A
	MSDS	ChineseUSA	Flash Point	346.3±31.5 °C

Purity		Quantity		Budget		Inquiry

Use of Vitamin E Nicotinate (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].

• Properties

• Articles25

• Spectrum

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 Names

Name	(±)-α-Tocopherol nicotinate
Synonym	More Synonyms

 Vitamin E Nicotinate Biological Activity

Description	(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	(±)-α-Tocopherol nicotinate can help slow the progression of microangiopathy in type 2 diabetics by reducing lipid peroxidation stress in the red blood cell membrane, improving blood rheology and red blood cell deformability[1]. (±)-α-Tocopherol nicotinate (Vitamin E) (2 μg/mL, 24 h) increases the proportion of CD4+CD8-T cells in thymocytes by pretreating the thymic epithelial cell line IT45-R1 and then incubating it with immature T cells[2].
In Vivo	(±)-α-Tocopherol nicotinate (Vitamin E) (in animal feedings, 50 mg/kg or 585 mg/kg, 7 weeks) significantly increases the proportion of CD4+CD8- T cells and the expression of ICAM-1 in thymic epithelial cells (TECs) isolated of male Fisher rats at high dose concentrations of 585 mg/kg compared to low dose treatment of 50 mg/kg[2].
References	[1]. T W Chung, et al. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med. 1998 May;15(5):380-5. [2]. Satoru Moriguchi, et al.Vitamin E enhances T cell differentiation through increased epithelial cell function in rat thymus,Nutrition Research,Volume 17, Issue 5,1997,Pages 873-883.

 Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	649.0±55.0 °C at 760 mmHg
Molecular Formula	C35H53NO3
Molecular Weight	535.800
Flash Point	346.3±31.5 °C
Exact Mass	535.402527
PSA	48.42000
LogP	13.23
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.514
Storage condition	2-8°C

 MSDS

Vitamin E Nicotinate MSDS(Chinese)

 Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Company Profile

    Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.

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