Vildagliptin dihydrate NEW
| Price | $2140 | $2785 | $3520 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: Vildagliptin dihydrate | CAS No.: 2133364-01-7 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | Vildagliptin dihydrate |
| Description | Vildagliptin dihydrate (LAF237 dihydrate) is a potent and stable dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells, exhibiting exceptional oral bioavailability and significant antihyperglycemic activity [1]. |
| In vitro | Vildagliptin enhances beta cell longevity by preventing apoptosis (cell death) and encouraging cell proliferation [2]. |
| In vivo | Vildagliptin, administered orally at doses of 35 mg/kg once daily via gavage, effectively increases plasma active GLP-1 levels in the islets of db/db mice, as shown by elevated GLP-1 levels from 11.69±0.44 to 22.63±1.19 after 6 weeks. In a similar vein, when given orally at a dosage of 10 μmol/kg to obese male Zucker rats, vildagliptin significantly reduces glucose excursions and enhances insulin secretion. These findings demonstrate vildagliptin's potential in modulating glucose metabolism and insulin secretion in different animal models of diabetes. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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