VAPREOTIDE NEW
| Price | $8 | $6 | $5 |
| Package | 1kg | 10kg | 100kg |
| Min. Order: | 1kg |
| Supply Ability: | 100kg |
| Update Time: | 2025-06-12 |
Product Details
| Product Name: VAPREOTIDE | CAS No.: 103222-11-3 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 100kg | Release date: 2025/06/12 |
| Lead time: In stock | Packaging: bag/bottle/drum//IBC, as request |
| Delivery: By sea, by air, by express | Origin: Manufacturer |
| Name | rc 160 |
|---|---|
| Synonym | More Synonyms |
| Description | Vapreotide is a NK1R antagonist, with an IC50 of 330 nM. Sequence: Phe-Cys-Tyr-Trp-Lys-Val-Cys-Trp-NH2(Disulfide bridge: Cys2-Cys7). |
|---|---|
| Related Catalog | Signaling Pathways >> Others >> Others Peptides Research Areas >> Cancer |
| Target | 330 nM (NK1R)[1]. |
| In Vitro | Vapreotide attenuates the effect of SP on calcium release in a concentration-dependent manner. The concentration required for Vapreotide to completely inhibit the effect of SP is about 100 times higher than that required for the NK1R antagonist aprepitant. The effect of Vapreotide on cell proliferation is mediated primarily by SSTR2. In order to further establish the NK1R antagonist effect of Vapreotide, U373MG cells are pretreated with SSTR2 selective antagonist CYN followed by incubation with Vapreotide and SP stimulation. The results show that pretreatment with CYN does not reverse the inhibitory effect of Vapreotide on SP-stimulated IL-8 mRNA expression. Vapreotide reduces HIV-1 replication in MDM as indicated by limited HIV gag mRNA expression compared to control MDM. In addition, SP treatment (10 μM) reverses Vapreotide inhibition of HIV-1 replication in MDM. This observation indicates that the inhibition of HIV-1 replication by Vapreotide is most likely due to its interaction with NK1R[1]. |
| Cell Assay | The HEK293-NK1R cells and U373MG cells are incubated with or without Vapreotide (0, 5, 10, 20 μM) for 10 minutes and then incubated with or without SP for 3 hours. In some experiments, cells are first incubated with CYN for 10 minutes, and then Vapreotide is added and incubated for an additional 10 minutes, followed by stimulation with SP for 3 hours. Mock treated cells are used as controls[1]. |
| References | [1]. Spitsin S et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20(5):247-55. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 1540.9±65.0 °C at 760 mmHg |
| Molecular Formula | C57H70N12O9S2 |
| Molecular Weight | 1131.371 |
| Flash Point | 885.7±34.3 °C |
| Exact Mass | 1130.483032 |
| PSA | 401.24000 |
| LogP | 3.47 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.699 |
| Storage condition | ?20°C |
| Safety Phrases | 22-24/25 |
|---|
Company Profile
Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.
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Our products have been exported to many countries, including Germany, Spain, the United Kingdom, the United States, Australia, the Middle East, Asia, and more. We have received highly positive feedback from our clients and have established long-term friendly cooperative relationships with them.
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Excellent quality is one of the cornerstones of our success. We welcome ordering samples for quality testing.
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We assist buyers in customs clearance by providing necessary documents and information.
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? Packaging:
1kg/bag, 25kg/drum, 50kg/drum, 180kg/drum, 200kg/drum, 1T/bag/drum, standard export packaging or packaging required by customers
? Shipping
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Within 7 days after receiving your payment
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Contact name: Tina
Email address: Tina@fdachem.com
Mob: 86 13213167925
WhatsApp/Skype/Wechat/LINE: 86 15225627621
Company Profile Introduction
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