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Postion:Product Catalog >API>Antibiotics>Other antibiotic Drugs>Valinomycin
Valinomycin
  • Valinomycin
  • Valinomycin
  • Valinomycin
  • Valinomycin
  • Valinomycin

Valinomycin NEW

Price Get Latest Price
Package 1g 25g
Min. Order: 1g
Supply Ability: 1000g
Update Time: 2025-07-25

Product Details

Product Name: Valinomycin CAS No.: 2001-95-8
EC-No.: 217-896-6 Min. Order: 1g
Purity: 95.06% Supply Ability: 1000g
Release date: 2025/07/25

Valinomycin is a naturally occurring cyclic dodecadepsipeptide antibiotic (12 amino acid-like residues) produced by Streptomyces bacteria. Here's what makes it significant:

Potassium (K?) Ionophore: Its core function is to act as a highly selective carrier for potassium ions (K?). Its unique structure (alternating D- and L-hydroxy and amino acids, ester and amide bonds) forms a hydrophilic interior that perfectly binds K? and a hydrophobic exterior that dissolves in lipid membranes.

Mechanism: It shuttles K? ions down their concentration gradient across biological membranes:

    • Binds K? on one side of the membrane.

    • Diffuses through the lipid bilayer.

    • Releases K? on the other side.

      Biological Effect: This disrupts essential electrochemical gradients (especially the K? gradient and the membrane potential ΔΨ).

    • Uncouples Oxidative Phosphorylation: By dissipating the proton gradient (H?) in mitochondria (indirectly via ΔΨ collapse), it halts ATP production.

    • Disrupts Cellular Ion Balance: Affects osmotic balance, nerve impulses, muscle contraction, etc.

      Toxicity: Its ability to collapse membrane potentials makes it highly toxic to cells, bacteria, mitochondria, and even mammals. It's primarily used as a research tool.

      Applications:

    • Research Tool: Induces apoptosis, studies ion transport, uncouples mitochondria, probes membrane potential.

    • (Historical) Antibiotic: While effective against some bacteria (especially Gram-positive) and fungi, its toxicity limits therapeutic use.

In short: Valinomycin is a potassium-selective ionophore that destroys vital membrane potentials by ferrying K? ions across membranes, making it a potent toxin and valuable research tool for studying bioenergetics and transport.

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Company Profile Introduction

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber. Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement. We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

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  • Since: 2006-04-03
  • Address: Room 2015, No.2 Building Kaixin Mansion, No.107 Jinqiao Ave, Wuhan, China
INQUIRY
Betty Shu
+86-13986145403
info@fortunachem.com