
Valinomycin NEW
Price | Get Latest Price | |
Package | 1g | 25g |
Min. Order: | 1g |
Supply Ability: | 1000g |
Update Time: | 2025-07-25 |
Product Details
Product Name: Valinomycin | CAS No.: 2001-95-8 |
EC-No.: 217-896-6 | Min. Order: 1g |
Purity: 95.06% | Supply Ability: 1000g |
Release date: 2025/07/25 |
Valinomycin is a naturally occurring cyclic dodecadepsipeptide antibiotic (12 amino acid-like residues) produced by Streptomyces bacteria. Here's what makes it significant:
Potassium (K?) Ionophore: Its core function is to act as a highly selective carrier for potassium ions (K?). Its unique structure (alternating D- and L-hydroxy and amino acids, ester and amide bonds) forms a hydrophilic interior that perfectly binds K? and a hydrophobic exterior that dissolves in lipid membranes.
Mechanism: It shuttles K? ions down their concentration gradient across biological membranes:
Binds K? on one side of the membrane.
Diffuses through the lipid bilayer.
Releases K? on the other side.
Biological Effect: This disrupts essential electrochemical gradients (especially the K? gradient and the membrane potential ΔΨ).
Uncouples Oxidative Phosphorylation: By dissipating the proton gradient (H?) in mitochondria (indirectly via ΔΨ collapse), it halts ATP production.
Disrupts Cellular Ion Balance: Affects osmotic balance, nerve impulses, muscle contraction, etc.
Toxicity: Its ability to collapse membrane potentials makes it highly toxic to cells, bacteria, mitochondria, and even mammals. It's primarily used as a research tool.
Applications:
Research Tool: Induces apoptosis, studies ion transport, uncouples mitochondria, probes membrane potential.
(Historical) Antibiotic: While effective against some bacteria (especially Gram-positive) and fungi, its toxicity limits therapeutic use.
In short: Valinomycin is a potassium-selective ionophore that destroys vital membrane potentials by ferrying K? ions across membranes, making it a potent toxin and valuable research tool for studying bioenergetics and transport.
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- Since: 2006-04-03
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