Upadacitinib Impurity 6；

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

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• Product Information

• Product Number: U003006

• English Name: Upadacitinib Impurity 6

• English Alias: 1686678.0; (3R,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide

• CAS Number: None

• Molecular Formula: C??H??F?N?O

• Molecular Weight: 380.37

• Advantages

• As a key related impurity of Upadacitinib, its research is vital for drug development and quality control:
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• Helps analyze the synthesis process of Upadacitinib to optimize production and reduce impurity formation;

• Aids in evaluating drug metabolism, providing references for safety and efficacy studies;

• Serves as a reference standard for impurity quantification to ensure drug purity meets pharmacopoeia standards.

• Applications

• Drug Development: Used as an impurity reference standard to identify and quantify the impurity, assisting in drug quality assessment;

• Quality Control: Acts as a standard substance to validate the accuracy of detection methods, ensuring drug stability during production and storage;

• Toxicological Research: Assists in evaluating the potential impact of the impurity on humans to establish safe impurity limits.

• Background Description

• Upadacitinib, a highly selective JAK1 inhibitor, is clinically used for treating immune-related diseases like rheumatoid arthritis and atopic dermatitis. Impurities in drugs may affect efficacy or cause safety issues, making impurity research a core part of drug quality control. Upadacitinib Impurity 6, potentially generated during synthesis or storage, requires systematic study to clarify its source, properties, and control methods.

• Research Status

• Current research focuses on:
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• Synthesis Methods: Developing efficient and high-purity preparation processes to meet research and quality control needs;

• Detection Technologies: Establishing highly sensitive impurity analysis methods using LC-MS, NMR, etc.;

• Formation Mechanism: Investigating the generation pathway of the impurity during synthesis and storage to optimize processes for reduction;

• Safety Assessment: Determining the safe exposure level of the impurity through toxicological experiments to support drug standard formulation

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!