Product Details
| Product Name:
UC-1V150 |
CAS No.:
927822-45-5 |
| Supply Ability:
10g |
Release date:
2025/05/02 |
Product Introduction
Bioactivity
| Name | UC-1V150 |
| Description | UC-1V150 is a distinct TLR7 agonist, which activates cellular immune responses and exhibits anti-tumor effects. It also serves as a precursor for the synthesis of ISAC molecules, known as immune-stimulating antibody conjugates [1] [2]. |
| In vitro | UC-1V150, at concentrations ranging from 0.01 to 10 μM over a 24-hour period, effectively promotes the secretion of IL-6 and IL-2 cytokines in bone-marrow-derived macrophages [1]. Additionally, when administered at 1 μg/mL for 48 hours, it enhances the expression of FcγRIIA and FcγRIII and induces a roughly 1.5-fold enhancement in the phagocytosis index of target cells in human monocyte-derived macrophages (hMDM) [2]. |
| In vivo | UC-1V150, administered via a single intravenous injection at concentrations ranging from 0.38-38 nM for 2 hours, effectively triggers the release of serum cytokines in female C57BL/6 mice aged 5-6 weeks. This administration resulted in serum interleukin-6 (IL-6) levels reaching approximately 0.1 ng/mL and interleukin-2 (IL-2) levels reaching approximately 1.5 ng/mL at the 38 nM concentration. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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