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Postion:Product Catalog >API>Hormones and the Endocrine System>Pancreatic hormone and blood sugar regulation>TOFOGLIFLOZIN
TOFOGLIFLOZIN
  • TOFOGLIFLOZIN

TOFOGLIFLOZIN

Price Get Latest Price
Package 25kg
Min. Order: 1kg
Supply Ability: 10000KGS
Update Time: 2025-06-09

Product Details

Product Name: TOFOGLIFLOZIN CAS No.: 1201913-82-7
Min. Order: 1kg Purity: 99%
Supply Ability: 10000KGS Release date: 2025/06/09

Product Description:

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

Email & Skype: 1023@dideu.com Telephone:+86-29-89586680

DescriptionTofogliflozin hydrate, which is a sodium-glucose co-transporter 2 inhibitor, was approved in Japan for the treatment of type 2 diabetes at the same time as luseogliflozin hydrate (XIX). The drug was discovered by Chugai Pharmaceutical and jointly developed with Sanofi-Aventis and Kowa. Tofogliflozin hydrate reduces glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2, and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys.
SynthesisReduction of commercially available 2-bromoterephtalic acid (268) through the use of trimethoxyborane and borane- THF proceeded in 89% yield to afford diol 269. Subjection of this compound to 2-methoxypropene (270) under acidic conditions generated bis-acetonide 271. This bromide then underwent lithium¨Chalogen exchange followed by exposure to magnesium bromide and treatment with lactone 272 (which was prepared by persilylation of commercially available (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2Hpyran- 2-one (277). This mixture was worked up with aqueous ammonium chloride and upon treatment with p-TsOH in methanol resulted in spiroacetal 273. Next, global protection of all alcohol functionalities within 273 was affected by reaction with methylchloroformate and DMAP in acetonitrile. The benzyl carbonate within 274 was selectively exchanged via Suzuki coupling with 4-ethylphenylboronic acid (275) to afford methylene dibenzyl system 276. Subsequent treatment with aqueous sodium hydroxide in methanol followed by crystallization from 1:6 acetone and water furnished the desired product tofogliflozin hydrate (XXXIV) in 75% yield.

Mobile/Whatsapp/Wechat: +8618192503167


Packaging & Shipping:

Our normal packaging is 25kgs/Drum

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Our Services:

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

FAQ:

Why do you choose Dideu as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001; 2015 and have GMP certification. Free sample can be arranged before shipment and SGS, BV and other third party inspection company are accepted before loading. For regular customers, we accept L/C 180 Days, D/P, D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.






Company Profile Introduction

Dideu is a high-tech enterprise, which excels in the fields of R&D, production and sales, making it a pioneer in cutting-edge technologies. With a focus on pharmaceutical and small molecule drugs R&D, pharmaceutical intermediates, new bio-based molecules and materials, biopharmaceuticals, genetic engineering bacterial biosynthesis enzymes, CMO/CDMO custom chemicals and liquid crystal OLED materials. Dideu has witnessed rapid growth in recent years, with thriving businesses in original drug research, biopharmaceuticals, biodegradable materials and pharmaceutical intermediates. Dideu always takes on some of the human biggest healthcare challenges. It delivers a sustainable business and health benefits to patients through its high quality products. Dideu develops a broad range of products in pharmaceuticals, vaccines and consumer healthcare, and has leading products across various therapeutic areas including cardiovascular and respiratory disease,neurological disorders, asthma, cancer, infections, mental health, gastrointestinal infection,diabetes and digestive conditions. It is one of the best companies to have a good growth in emerging markets recent years; Dideu is improving people’s quality of life by preventing, alleviating and treating diseases. And we are also have subsidiary company helping to provide a reliable supply of high quality green agrucutural chemical, high-quality food, feed and plant-based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company’s earning power. We

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