Product Details
| Product Name:
TH-Z835 |
CAS No.:
2766209-50-9 |
| Supply Ability:
10g |
Release date:
2025/07/20 |
Product Introduction
Bioactivity
| Name | TH-Z835 |
| Description | TH-Z835 is a mutant-selective KRAS(G12D) inhibitor with an IC50 of 1.6 μM.This compound inhibits mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange. |
| In vitro | TH-Z835 reduces pERK levels in PANC-1 cells with an IC50 value less than 2.5 μM [1]. Additionally, TH-Z835 exhibits antiproliferative effects in various non-G12D mutant cancer cell lines, including 4T1 (KRAS(WT)), MIA PaCa-2 (KRAS(G12C)), CFPAC-1 (KRAS(G12V)), and HCT116 (KRAS(G13D)), by decreasing pERK and pAKT levels and inducing apoptosis, indicating off-target effects [1]. |
| In vivo | TH-Z835 (10mg/kg; intraperitoneal injection) reduces tumor volume in a C57BL/6 mouse model. In vivo, TH-Z835 induces apoptosis and inhibits MAPK signaling [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | ML-210 | CCG-257081 | CCG-203971 | Ketoconazole | Deltarasin | ZCL278 | Salirasib | RMC-6236 | Rhosin hydrochloride | (S)-(-)-Perillyl alcohol | CASIN | Cysmethynil |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
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$67.00/2mg |
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United States