Tetrandrine NEW
| Price | $43 | $89 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-24 |
Product Details
| Product Name: Tetrandrine | CAS No.: 518-34-3 |
| Purity: 99.13% | Supply Ability: 10g |
| Release date: 2025/07/24 |
Product Introduction
Bioactivity
| Name | Tetrandrine |
| Description | Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels. |
| In vitro | METHODS: Leukemia cell lines K562, THP-1, U937, and HL60 were treated with Tetrandrine (1-3 μM) for 24-72 h, and cell numbers were measured. RESULTS: 2 μM and 3 μM Tetrandrine significantly inhibited cell proliferation. [1] METHODS: A panel of GFP-LC3-expressing tumor cell lines MCF-7, PLC-5, SK-Hep1, HeLa, and PC3 cells were treated with Tetrandrine (5 μM) for 16 h and GFP-LC3 spots were detected. RESULTS: Tetrandrine significantly induced GFP-LC3 spot formation with similar potency (5 μM) in all cell lines tested.Tetrandrine induced autophagy in multiple cell lines. [2] |
| In vivo | METHODS: To detect anti-tumor activity in vivo, athymic nude mice bearing THP-1 xenografts were administered Tetrandrine (25-50 mg/kg, 0.5% methylcellulose) by gavage once daily for 13 days. RESULTS: Tetrandrine treatment reduced tumor growth. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 0.7 mg/mL (1.12 mM), Solution. DMSO : 12.45 mg/mL (19.99 mM), Sonication and heating are recommended. |
| Keywords | Tetrandrine | PotassiumChannel | Potassium Channel | NSC77037 | NSC 77037 | KcsA | Inhibitor | inhibit | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels |
| Inhibitors Related | Minoxidil sulfate | Tannic acid | L-Ascorbic acid | Hydrochlorothiazide | L-Phenylalanine | D-Menthol | Ethyl cinnamate | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Chlorzoxazone | Indapamide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Antiparasitic Natural Product Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ion Channel Targeted Library | Anti-Cancer Drug Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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