Tetrahydromagnolol

Modify Date: 2024-01-07 09:21:37

Tetrahydromagnolol structure	Common Name	Tetrahydromagnolol
	CAS Number	20601-85-8	Molecular Weight	270.366
	Density	1.1±0.1 g/cm3	Boiling Point	400.5±40.0 °C at 760 mmHg
	Molecular Formula	C18H22O2	Melting Point	N/A
	MSDS	N/A	Flash Point	182.2±21.9 °C

Purity		Quantity		Budget		Inquiry

Use of Tetrahydromagnolol Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].

• Properties

• Spectrum

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 Names

Name	2-(2-hydroxy-5-propylphenyl)-4-propylphenol
Synonym	More Synonyms

 Tetrahydromagnolol Biological Activity

Description	Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> GPR55 Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB2:170 nM (EC50) CB2:416 nM (Ki) CB1:9010 nM (EC50) CB1:2260 nM (Ki) GPR55 receptor
References	[1]. Alexander Fuchs, et al. The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One. 2013 Oct 30;8(10):e77739.

 Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	400.5±40.0 °C at 760 mmHg
Molecular Formula	C18H22O2
Molecular Weight	270.366
Flash Point	182.2±21.9 °C
Exact Mass	270.161987
PSA	40.46000
LogP	4.95
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.577

 Safety Information

HS Code	2907299090

 Synthetic Route

Previous 1/5 Next

2,2'-dimeth... 860589-82-8 ~% Tetrahydromagno... 20601-85-8

Literature: Sugii Yakugaku Zasshi, 1930 , vol. 50, p. 183,201; dtsch. Ref. S. 24 Chem.Abstr., 1930 , p. 3505

4-Propylphenol 645-56-7 ~13% Tetrahydromagno... 20601-85-8

Literature: Kong, Zwe-Ling; Tzeng, Shin-Cheng; Liu, Yeuk-Chuen Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 163 - 166

N/A 1413440-39-7 2-Bromo-4-propy... 64080-16-6 ~24% Tetrahydromagno... 20601-85-8

Literature: Rempel, Viktor; Fuchs, Alexander; Hinz, Sonja; Karcz, Tadeusz; Lehr, Matthias; Koetter, Uwe; Mueller, Christa E. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 1 p. 41 - 45

 Precursor & DownStream

Precursor  8	Previous 1/2 Next
CAS#:860589-82-8 2,2'-dimethoxy-...  CAS#:645-56-7 4-Propylphenol  CAS#:1806-29-7 biphenol  CAS#:4877-93-4 2,2'-dimethoxyb...
DownStream  0

 Customs

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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