TD-5471 hydrochloride NEW
| Price | $700 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-29 |
Product Details
| Product Name: TD-5471 hydrochloride | CAS No.: 530084-35-6 |
| Purity: 99.57% | Supply Ability: 10g |
| Release date: 2025/07/29 |
Product Introduction
Bioactivity
| Name | TD-5471 hydrochloride |
| Description | TD-5471 hydrochloride is a selective and potent long-acting human β2-adrenergic receptor agonist for the treatment of chronic obstructive pulmonary disease (COPD). |
| In vitro | In an in vitro guinea pig trachea model, TD-5471 exhibits potent activity with a slow onset. Its potency is evident, as indicated by a pEC50 of 8.7 in the guinea pig tracheal ring assay. Notably, TD-5471 is structurally distinct from Milveterol, and its prolonged duration of action aligns with a correlation observed in other long-acting β2-agonist discovery programs, specifically related to hydrophobicity[1]. |
| In vivo | In an in vivo guinea pig model of bronchoprotection, TD-5471 demonstrates a prolonged and dose-dependent duration of action. The efficacy of TD-5471 is notably high, as evidenced by its excellent potency measured 1.5 hours after nebulized dosing. To ensure suitability for once-daily dosing in humans, a 72-hour time point is chosen, considering that a high dose of Salmeterol (300 μg/mL) provides bronchoprotection lasting ≥24 hours in this model. At the 72-hour time point, TD-5471-mediated bronchoprotection remains dose-dependent and significantly surpasses the efficacy of Salmeterol at nebulizer concentrations of ≥30 μg/mL[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | β2-adrenergic receptor | β2 adrenoceptor | TD-5471 Hydrochloride | TD5471 hydrochloride | TD5471 Hydrochloride | TD 5471 hydrochloride | TD 5471 Hydrochloride | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Olanzapine | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Amitriptyline hydrochloride | Isoprenaline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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