TBK1/IKKε-IN-4 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-20 |
Product Details
| Product Name: TBK1/IKKε-IN-4 | CAS No.: 1381930-17-1 |
| Supply Ability: 10g | Release date: 2025/07/20 |
Product Introduction
Bioactivity
| Name | TBK1/IKKε-IN-4 |
| Description | TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced activity, by 100- to 1000-fold, against other protein kinases, such as PDK1, PI3K family members, and mTOR[1]. |
| In vitro | TBK1/IKKε-IN-4 (Compound II; 96 hours; A549 and HCC44 cells) demonstrates selective toxicity in TBK1-dependent cancer cell lines (IC50 of ~4.2 μM for H441 cells and IC50 of ~0.4 μM for A549 cells)[1]. TBK1/IKKε-IN-4 (Compound II; 0-2 μM; 30 minutes; HCC44 cells) inhibits AKT activity[1]. TBK1/IKKε-IN-4 (Compound II) inhibits LPS-induced expression of IFNβ (IC50 = 62 nM) and the IFNβ target genes IP10 (IC50 = 78 nM) and Mx1 (IC50 = 20 nM). It effectively blocks TLR3-dependent IRF3 nuclear translocation (IC50 < 100 nM) without impairing TNFR1-dependent p65 NFκB nuclear translocation at doses up to 20 μM[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 70 mg/mL (131.18 mM), Sonication is recommended. |
| Keywords | TBK1/IKKε IN 4 | TBK-1/IKKε-IN-4 | TBK1/IKKεIN4 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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