TAME NEW
| Price | $46 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: TAME | CAS No.: 901-47-3 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | TAME |
| Description | TAME (Tosyl-Arginine Methyl Este), an inhibitor of the late-promoting complex (APC/C or APC), inhibits APC-dependent protein hydrolysis by competing for APC binding with the C-terminal isoleucine-arginine tail of the APC activator cytokinesis cycle 20 (Cdc20). TAME binds to and prevents APC binding by Cdc20 and Cdh20. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. |
| In vitro | In the absence of an APC substrate, TAME repels Cdc20 from APC by inducing its auto-ubiquitination in its N-terminal region, while Cyclin B1 counteracts the effect of TAME by promoting the binding of free Cdc20 to APC and inhibiting the auto-ubiquitination of Cdc20. TAME stabilized Cyclin B1 in African Xenopus extracts by two mechanisms. First, TAME reduced the kcat value of the APC^Cdc20/cyclin B1 complex without affecting the Km value, thereby slowing down the initial ubiquitination process of unmodified Cyclin B1. Second, as Cyclin B1 is progressively ubiquitinated, it gradually loses its ability to promote Cdc20 binding to APC in the presence of TAME. As a result, the ubiquitination of Cyclin B1 is terminated before reaching the threshold at which protein hydrolysis is required. [2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 63 mg/mL (183.99 mM), Sonication is recommended. Ethanol : 3 mg/mL (8.76 mM), Sonication is recommended. DMSO : 80 mg/mL (233.64 mM), Sonication is recommended. |
| Keywords | Tosylarginine methyl ester | TAME | N-4-Tosyl-L-arginine methyl ester | APC | Anaphase promoting complex |
| Inhibitors Related | TAME hydrochloride | TASIN-1 | TASIN-1 Hydrochloride | TASIN-30 | Apcin | Apcin A HCL | CFM 4 | Activated Protein C (390-404), human acetate |
| Related Compound Libraries | Cell Cycle Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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