Product Details
Product Name:
Tagitinin C |
CAS No.:
59979-56-5 |
Supply Ability:
10g |
Release date:
2025/05/09 |
Product Introduction
Bioactivity
Name | Tagitinin C |
Description | Tagitinin C is a sesquiterpene compound derived from Tithonia diversifolia, an inducer of ferroptosis with anti-cancer activity. It induces ferroptosis through the PERK-Nrf2-HO-1 signaling pathway. |
In vitro | Tagitinin C can inhibit the proliferation of human glioblastoma U373, IC50 = 6.1±0.1 μg /mL. [1]
Tagitinin C has cytotoxic activity against human hepatocellular carcinoma Hep-G2 cells with IC (50) = 2.0 ± 0.1 μg/mL. [2]
Tagitinin C induces iron death through ER stress-mediated activation of the PERK-Nrf2-HO-1 signaling pathway. It can be used as a new inducer of iron death. [3] |
In vivo | Tagitinin C (15 μg/ mouse/day) delayed tumorigenicity in Hep-G2 cell xenografts. [2] |
Storage | store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Inhibitors Related | TBHQ | Acetylcysteine | Butylated hydroxytoluene | α-Vitamin E | L-Glutamic acid | Sorafenib | Curcumin | Artemisinin | L-Cystine | L-Glutamine | L-Glutamic acid monosodium salt | Coenzyme Q10 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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