SW203668 (trifluoroacetate salt) NEW
| Price | Get Latest Price | ||
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-29 |
Product Details
| Product Name: SW203668 (trifluoroacetate salt) | CAS No.: 2117405-48-6 |
| Supply Ability: 10g | Release date: 2025/07/29 |
Product Introduction
Bioactivity
| Name | SW203668 (trifluoroacetate salt) |
| Description | SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. |
| In vivo | In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol:PBS (pH 7.2) (1:3) : 0.25 mg/mL (0.5 mM), Sonication is recommended. DMSO : 20 mg/mL (39.72 mM), Sonication is recommended. DMF : 20 mg/mL (39.72 mM), Sonication is recommended. Ethanol : 20 mg/mL (39.72 mM), Sonication is recommended. |
| Keywords | SW203668 (trifluoroacetate salt) | SW-203668 | SW203668 | SW-203668 (trifluoroacetate salt) | SW 203668 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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