SRI-41315 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-15 |
Product Details
| Product Name: SRI-41315 | CAS No.: 1613509-49-1 |
| Supply Ability: 10g | Release date: 2025/07/15 |
Product Introduction
Bioactivity
| Name | SRI-41315 |
| Description | SRI-41315, a chemical compound, effectively addresses premature termination codons (PTCs) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells. It induces a prolonged pause at stop codons, resulting in the restoration of cystic fibrosis transmembrane conductance regulator (CFTR) expression and function. This compound achieves PTC suppression by reducing the abundance of the termination factor eRF1. Additionally, SRI-41315 synergistically enhances CFTR activity by potentiating aminoglycoside-mediated readthrough [1]. |
| In vitro | SRI-41315 demonstrates cytotoxicity with CC50 values exceeding 50 μM in FRT and 16BE14o- cells, highlighting its enhanced potency and efficacy, particularly noticeable in FRT cells and correspondingly in 16HBE14o- cells. At a concentration of 5 μM over a 20-hour exposure, SRI-41315 effectively depletes eRF1 levels via a proteasome-mediated degradation pathway, as confirmed by Western Blot Analysis in CFTR-G542X 16HBEge G542X cells. Interestingly, the eRF1 degradation induced by SRI-41315 is inhibited by (S)-MG132, a proteasome inhibitor, but remains unaffected by the neddylation inhibitor MLN4924, suggesting a specific proteasomal degradation mechanism. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| $30.00/1mg |
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TargetMol Chemicals Inc.
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2025-06-17 | |
| $1520.00/25mg |
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TargetMol Chemicals Inc.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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