SPR741 acetate NEW
| Price | $183 | $465 | $633 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-09 |
Product Details
| Product Name: SPR741 acetate | Purity: 98.57% |
| Supply Ability: 10g | Release date: 2025/07/09 |
Product Introduction
Bioactivity
| Name | SPR741 acetate |
| Description | SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases. |
| In vitro | SPR741 acetate potentiates antibiotics ,SPR741 acetate are substrates of the AcrAB-TolC efflux pump in E. coli, effectively circumventing the contribution of this pump to intrinsic antibiotic resistance. The intrinsic resistance of E. coli to certain antibiotics that is mediated by both the outer membrane and the AcrAB-TolC efflux system can be overcome, or circumvented, by combining the antibiotic with SPR741 acetate but that potentiation of intrinsic resistance due primarily to efflux may be limited.[1] |
| In vivo | SPR741 acetate has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus makeing them sensitive to hydrophobic antibiotics. SPR741 acetate has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. Polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741 acetate in multiday rodent and nonhuman primate studies.[1] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 117.0 mg/mL (111.2 mM), Sonication is recommended. |
| Keywords | SPR-741 Acetate | SPR741 Acetate | SPR 741 Acetate | NAB-741 Acetate | NAB741 Acetate | NAB 741 Acetate | Bacterial | 1179330-52-9 free base | 1179330-52-9 |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Doxycycline (hyclate) | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Penicillin G potassium | Doxycycline hydrochloride | Ethyl acetoacetate |
| Related Compound Libraries | Peptide Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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