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Postion:Product Catalog >Spiroxatrine
Spiroxatrine
  • Spiroxatrine

Spiroxatrine NEW

Price $80 $128 $263
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-11

Product Details

Product Name: Spiroxatrine CAS No.: 1054-88-2
Purity: 99.83% Supply Ability: 10g
Release date: 2025/07/11

Product Introduction

Bioactivity

NameSpiroxatrine
DescriptionSpiroxatrine (R 5188) is a selective and potent 5-HT1α and α2-adrenergic dual antagonist with sedative activity, and inhibitory effects on 5-HT1α, 5-HT1β, 5-HT2, and dopamine receptors. Spiroxatrine may be used in the study of disorders related to the cardiovascular system.
In vitroSproxatrine (0.01-0.1 μM, 15 mins) enhances contraction in the vas deferens tissue of α2A/D-adrenergic receptor knockout mice[2].
In vivoSproxatrine (1-25 μg, intraperitoneal injection, 5 days) increases withdrawal latency to thermal and mechanical stimuli in the hind paw of nerve-injured rats and carrageenan-induced inflammatory rats[3]. Sproxatrine (4 mg/kg/day, intraperitoneal injection, 5 minutes) enhances the effect of Fluoxetine in reducing selectively bred alcohol-preferring (P) rat's voluntary oral ethanol intake[3].
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : < 1 mg/mL (insoluble or slightly soluble)
Keywordsα2 adrenergic receptor | DopamineReceptor | Dopamine Receptor | AdrenergicReceptor | Adrenergic Receptor | 5HTReceptor | 5-HT1B | 5-HT1A | 5HT Receptor
Inhibitors RelatedAlverine citrate | Dapoxetine hydrochloride | Clozapine N-Oxide | Octopamine hydrochloride | Dexmedetomidine hydrochloride | D-Menthol | Citicoline | Amitriptyline hydrochloride | Oxolinic acid | Trazodone hydrochloride | Mianserin hydrochloride | Cinchonidine
Related Compound LibrariesBioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Adrenergic Receptor-Targeted Compound Library | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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