Specnuezhenide NEW
| Price | $32 | $48 | $81 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: Specnuezhenide | CAS No.: 39011-92-2 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | Specnuezhenide |
| Description | Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling, thereby suppressing IL-1β-induced chondrocyte inflammation. It exerts anti-inflammatory effects in a rat model of osteoarthritis (OA). |
| In vitro | METHODS: Chondrocytes were pretreated with Specnuezhenide (Nuezhenide) (0, 10, 50, 100, 200 μM) for 1 hour and then incubated with IL-1β (5 ng / ml) for 24 hours. Real-time fluorescence quantitative PCR was used to detect the mRNA expression of MMP3, MMP9, IL-6, iNOS, COX2, type II collagen and sox9; Chondrocytes were pretreated with SPN of Specnuezhenide (Nuezhenide) (0, 50, 100, 200 μM) for 1 hour and then incubated with IL-1β (5 ng / ml) for 48 hours. After harvesting the cells for protein blotting. The protein levels of MMP3, MMP9, IL-6, iNOS, COX2, type II collagen and sox9 were detected by Western blot. RESULTS Specnuezhenide (Nuezhenide) treatment downregulated the expression of MMP3, MMP9, IL-6, iNOS and COX2; Specnuezhenide (Nuezhenide) treatment downregulated the expression of COX2. A significant decrease in the protein levels of MMP3, MMP9, IL-6 and iNOS was observed in the high concentration group (200 μM). A significant increase in the protein levels of collagen II and sox9 was observed only in the 200 μM Specnuezhenide (Nuezhenide) treatment group. [1] |
| In vivo | METHODS: An OA model was established in SD rats by surgical transaction of ACL and MM. Rats in the Specnuezhenide (Nuezhenide) group were intra-articularly injected with 200μl Specnuezhenide (Nuezhenide) solution (200μM, 0.14mg/kg) every 7 days. Histological evaluation based on OASRI was used to evaluate the OA grade and observe the effect of Specnuezhenide (Nuezhenide) treatment on cartilage degeneration in OA rats. RESULTS The average OARSI grade of the SPN group was 2.95, and the level of inflammatory factors in the Specnuezhenide (Nuezhenide) group was reduced. Specnuezhenide (Nuezhenide) treatment played a chondroprotective role in the OA rat model. [1] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (80.1 mM), Sonication is recommended. |
| Keywords | βcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | Specnuezhenide | osteoarthritis | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | diabetic retinopathy | beta-catenin | betacatenin | bcatenin | anti-angiogenic | (8E)-Nuezhenide |
| Inhibitors Related | Naringin dihydrochalcone | Lidocaine | Baicalin | Methylamine HCl | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | N,N-Dimethylacetamide | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Neuroprotective Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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