Product Details
| Product Name:
Sotrovimab |
CAS No.:
2423014-07-5 |
| Purity:
98.7% (SDS-PAGE); 98.5% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2025/07/28 |
Product Introduction
Bioactivity
| Name | Sotrovimab |
| Description | Sotrovimab (VIR 7831) is a monoclonal antibody against the SARS-CoV-2 virus that causes COVID-19. It has antiviral activity, induces serum neutralization of BQ.1 and antibody-dependent cytotoxicity, and may be used to study viral infections. |
| In vitro | Sotrovimab neutralizes SARS-CoV-2 and SARS-CoV but does not directly block viral receptor binding. Sotrovimab injected into the culture medium for 200 seconds at a concentration of 100 μg/mL (flow rate of 30 μL/min) was effective in binding to the surface-expressed SARS-CoV-2 S protein.Sotrovimab treated for 30 minutes at concentrations ranging from 0.3 ng/mL to 20 mg/mL exhibited in vitro neutralization of SARS-CoV-2 pseudotyped virus, and in vitro neutralization of Alpha, Beta, Gamma, and SARS-CoV. Sotrovimab exhibited in vitro neutralization of SARS-CoV-2 pseudotyped virus at concentrations ranging from 0.3 ng/mL to 20 mg/mL for 30 min, with IC50 values of 187.2 ng/mL, 71.9 ng/mL, 73.11 ng/mL, 51.3 ng/mL, and 118.64 ng/mL for the Alpha, Beta, Gamma, Delta, and Kappa variant viruses, respectively. [1][2] |
| In vivo | Sotrovimab was able to provide protective exposure to susceptible variants in the lungs of female crab-eating monkeys for up to 28 days after a single dose of 5 mg/kg (10 mL) was administered via intravenous catheter. [2] |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SARS-CoV | SARSCoV |
| Inhibitors Related | Nirmatrelvir | EIDD-1931 | Remdesivir | Silymarin | Molnupiravir | Umifenovir hydrochloride | Hydroxychloroquine | Ritonavir | Chloroquine phosphate | Chloroquine | Dexamethasone | Favipiravir |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States