Sivelestat sodium NEW
| Price | $30 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-22 |
Product Details
| Product Name: Sivelestat sodium | CAS No.: 150374-95-1 |
| Supply Ability: 10g | Release date: 2025/07/22 |
Product Introduction
Bioactivity
| Name | Sivelestat sodium |
| Description | Sivelestat sodium (EI 546 sodium) is a highly efficient inhibitor of human neutrophil elastase, improving sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway. It can be used in acute lung injury/acute respiratory distress syndrome research. |
| In vitro | Sivelestat sodium, a competitive inhibitor of human neutrophil elastase, has a Ki value of 200 nM, and does not inhibit trypsin, thrombin, fibrinolytic enzymes, plasma kallikrein-releasing enzyme, pancreatic kallikrein-releasing enzyme, chytolysin, or histone G, even at concentrations up to 100 μM. The IC50 values of Sivelestat sodium on neutrophil elastase in different species are 44 nM in humans, 36 nM in rabbits, 19 nM in rats, 37 nM in hamsters, and 49 nM in mice.[1] |
| In vivo | By intratracheal administration (0.021-2.1 mg/kg), Sivelestat sodium was able to effectively inhibit hamster lung hemorrhage induced by human neutrophil elastase (ID50 = 82 pg/kg), as well as the increase in guinea pig skin capillary permeability caused by i.v. administration (ID50 = 9.6 mg/kg). [1] Sivelestat sodium (10 mg/kg via tail vein infusion) ameliorated lung injury due to hemorrhagic shock in rats. [2] Sivelestat sodium was able to prevent ischemia-reperfusion injury in the bladder of rats by intraperitoneal injection (15 mg/kg and 60 mg/kg). [3] |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80.00 mg/mL (175.27 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Sivelestat sodium salt | Sivelestat sodium | ONO-5046 | ONO5046 | ONO 5046 | LY-544349 | LY544349 | LY 544349 |
| Inhibitors Related | Nirmatrelvir | EIDD-1931 | Remdesivir | Andrographolide | Silymarin | AEBSF hydrochloride | Umifenovir hydrochloride | Hydroxychloroquine | Ritonavir | Chloroquine phosphate | Dexamethasone | Favipiravir |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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