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Postion:Product Catalog >SEL120-34A HCl
SEL120-34A HCl
  • SEL120-34A HCl

SEL120-34A HCl NEW

Price $54 $128 $213
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-19

Product Details

Product Name: SEL120-34A HCl CAS No.: 1609452-30-3
Purity: 99.7% Supply Ability: 10g
Release date: 2025/07/19

Product Introduction

Bioactivity

NameSEL120-34A HCl
DescriptionSEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), with antitumor activity.
In vitroSEL120-34A HCl is a selective, ATP-competitive inhibitor of CDK8(IC50 of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively). SEL120-34A HCl is active against a panel of AML cell lines (GI50<1 μM), such as SKNO-1, KG-1, HEL-60, MOLM-16, MV-4-11, OciAML-2, MOLM-6 and OciAML-3 cells, consistent with the effective inhibition range of STAT1 S727 and STAT5 S726.
In vivoThe growth of tumor in mice bearing MV4-11 cancer cells inhibited by SEL120-34A (30, 60 mg/kg, p.o.), and also arrests the growth of KG-1-derived tumors at 30 mg/kg via oral administration.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 8.33 mg/mL (18.49 mM), Sonication is recommended.
KeywordsSEL120-34A HCl | SEL-120-34A HCl | SEL12034A HCl | SEL120 34A HCl | Inhibitor | inhibit | Cyclin dependent kinase | CDK9/cycT | CDK8/CycC | CDK19/CycC | CDK
Inhibitors RelatedRibociclib | Ro-3306 | Abemaciclib | Rafoxanide | AT7519 | Palbociclib monohydrochloride | CASIN | Palbociclib | GW 441756 | Sodium Oxamate | Dinaciclib | Abemaciclib methanesulfonate
Related Compound LibrariesBioactive Compound Library | Kinase Inhibitor Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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