SAR7334 NEW
| Price | $65 | $163 | $263 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: SAR7334 | CAS No.: 1333210-07-3 |
| Purity: 99.71% | Supply Ability: 10g |
| Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | SAR7334 |
| Description | SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM). |
| In vitro | SAR7334 is an inhibitor of TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226 nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents (IC50 of 7.9 nM). SAR7334 (100 nM) substantially reduces TRPC6 currents[3]. |
| In vivo | In isolated perfused lungs from mice, SAR7334 (10mg/kg, p.o.) inhibits TRPC6-dependent acute HPV . SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 350 mg/mL (951.42 mM), Sonication is recommended. |
| Keywords | TRPVChannel | TRPV Channel | TRPChannel | TRPC6 currents | TRPC6 | TRP Channel | Transient receptor potential channels | SAR-7334 | SAR7334 | SAR 7334 | Inhibitor | inhibit |
| Inhibitors Related | (+)-Camphor | Fingolimod hydrochloride | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Capsaicin | trans-Cinnamaldehyde | Methyl salicylate |
| Related Compound Libraries | Membrane Protein-targeted Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $46.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-05-31 | |
| $65.00/1mg |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-05-07 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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