S65487 hydrochloride NEW
| Price | $697 | $1490 |
| Package | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-19 |
Product Details
| Product Name: S65487 hydrochloride | CAS No.: 1644543-95-2 |
| Supply Ability: 10g | Release date: 2025/07/19 |
Product Introduction
Bioactivity
| Name | S65487 hydrochloride |
| Description | S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y, while exhibiting poor affinity for MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and possesses anticancer activities. |
| In vitro | S65487 hydrochloride engages with the BH3 hydrophobic groove of BCL-2, effectively inducing apoptosis in various hematological cancer cell lines while concurrently inhibiting cell proliferation. Its inhibitory concentration 50 (IC50s) values are in the low nanomolar (nM) range[1]. |
| In vivo | S65487 hydrochloride effectively induces complete regression of BCL-2-dependent RS4;11 tumors in vivo with just one intravenous (IV) administration. When administered weekly via IV at doses well tolerated by the organism, a combination of S65487 hydrochloride and the MCL-1-specific inhibitor, S64315/MIK665, results in strong and persistent regression of lymphoid malignancy xenograft models in both mice and rats[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | S 65487 Hydrochloride | S-65487 Hydrochloride | S-65487 hydrochloride | VOB 560 Hydrochloride | VOB560 Hydrochloride | VOB-560 Hydrochloride | S65487 Hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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