Product Details
| Product Name:
S07-2010 |
CAS No.:
1223194-71-5 |
| Purity:
98.13% |
Supply Ability:
10g |
| Release date:
2025/07/08 |
Product Introduction
Bioactivity
| Name | S07-2010 |
| Description | S07-2010 is an AKR1C3 inhibitor with potential anti-cancer activity, suppressing AKR1C3, AKR1C4, AKR1C1, and AKR1C2, inducing apoptosis in A549/DDP cells. S07-2010 exhibits significant cytotoxicity in MCF-7/DOX and A549/DDP. |
| In vitro | S07-2010 (0-25 μM, 48h) was shown to be cytotoxic to MCF-7/DOX and A549/DDP with IC50 = 127.5 and 5.51 μM.
In A549/DDP cells, S07-2010 can significantly reverse cancer cell resistance to DDP and inhibit tumor proliferation at low concentrations.
In A549/DDP cells, the CI values of S07-2010 ranged from 0.2 to 0.6, indicating a strong synergistic drug effect in the combination therapy.
S07-2010 (25 μM) can induce apoptosis of tumor cells. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (80.76 mM), Sonication is recommended.
|
| Inhibitors Related | Nrf2-ARE/hMAO-B/QR2 modulator 1 | Carvedilol phosphate hemihydrate | ASP-9521 | Metronidazole | Resveratrol | Pasiniazid | Dicoumarol | NAD+ | Apocynin | Triclosan | AKR1C1-IN-1 | Setanaxib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
-
CAS:876625-29-5
$130.00 / 2mg
-
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$2500.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2025-04-28 |
United States