S-methyl DM1 NEW
| Price | $1670 | $2180 | $2800 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: S-methyl DM1 | CAS No.: 912569-84-7 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | S-methyl DM1 |
| Description | S-methyl DM1, a thiomethyl derivative of Maytansine, binds to tubulin (Kd of 0.93 μM) and inhibits microtubule polymerization. |
| In vitro | S-methyl DM1, the primary cellular or liver metabolite of antibody-maytansinoid conjugates prepared with thiol-containing maytansinoids DM1[1], inhibits microtubule assembly at a half-maximal concentration of 4 μM. At 100 nM, S-methyl-DM1 (84%) suppresses dynamic instability more effectively than Maytansine (45%). Tritiated S-methyl-DM1 binds to 37 high-affinity sites per microtubule (Kd of 0.1 μM)[1]. Minimal inhibition occurs at 200 pM and is maximal at 3 nM. S-methyl DM1 (IC50 of 330 pM) is slightly more potent than Maytansine (IC50 of 710 pM)[2]. In MCF7 cells, S-methyl DM1 induces up to 80% accumulation of cells in G2/M compared to 30% in controls[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Tubulin | S-methyl DM-1 | S-methyl DM1 | Smethyl DM1 | S methyl DM1 | MicrotubuleAssociated | Microtubule Associated | ADCCytotoxin | ADC Cytotoxin |
| Inhibitors Related | Methotrexate | Flubendazole | N-Phenylbenzylamine | Mebendazole | Camptothecin | 4-Isopropoxybenzoic acid | Oxfendazole | Dexamethasone | Methylene Blue trihydrate | Griseofulvin | Paclitaxel | 4'-Demethylepipodophyllotoxin |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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