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Postion:Product Catalog >Riviciclib
Riviciclib
  • Riviciclib

Riviciclib NEW

Price $1820 $2380 $3100
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-17

Product Details

Product Name: Riviciclib CAS No.: 920113-02-6
Supply Ability: 10g Release date: 2025/07/17

Product Introduction

Bioactivity

NameRiviciclib
DescriptionRiviciclib is a potent inhibitor of cyclin-dependent kinase (CDK)(CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively),with antitumor activity on cisplatin-resistant cells.
In vitroRiviciclib (3-24 hours; 1.5 μM) reduces cyclin D1, Cdk4, and Rb levels in H-460 cells. Rb (retinoblastoma) phosphorylation at Ser780 decrease at 3 h. Riviciclib shows activity in human cancer cell lines, such as colon carcinoma, osteosarcomal, cervical carcinoma, and bladder carcinoma cells[2].Riviciclib shows no detectable cells in G1 and G2 in promyelocytic leukemia cells and arrest of cells in G1 in synchronized human non-small cell lung carcinoma (H-460) and human normal lung fibroblast (WI-38) cells[3].
In vivoRiviciclib in human xenograft mode with severe combined immunodeficient mice shows significant inhibition in the growth of human colon carcinoma HCT-116 xenograft[3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
KeywordsRiviciclib | P276-00 | CDK9-cyclin H | CDK9- Cyclin T1 | cdk6-cyclin D3 | cdk4-cyclin D1 | cdk2-cyclin E | cdk2-cyclin A | CDK1-Cyclin B

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Product name Price   Suppliers Update time
$40.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2025-07-17
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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