RAGE/SERT-IN-1 NEW
| Price | $1670 | $2180 | $2800 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: RAGE/SERT-IN-1 | CAS No.: 2766739-35-7 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | RAGE/SERT-IN-1 |
| Description | RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and 31.09 nM, respectively. It demonstrates significant neuroprotective effects against Aβ25-35-induced neuronal damage and alleviates depressive behavior in mice. RAGE/SERT-IN-1 is useful for research on the comorbidity of Alzheimer's disease and depression [1]. |
| In vitro | RAGE/SERT-IN-1 (compound 12) at concentrations of 1-20 μM, applied for 24 hours, does not significantly affect the viability of SH-SY5Y cells [1]. |
| In vivo | RAGE/SERT-IN-1 (0-10 μM; 60 min) shows robust liver microsomal stability and negligible inhibition of primary CYP enzymes [1]. Administered intraperitoneally (IP) at 100 and 200 mg/kg, it causes no mortality or significant organ-to-body weight ratio changes at 100 mg/kg in mice [1]. A single oral dose (60 mg/kg) significantly reduces immobility time in the tail suspension test, suggesting antidepressant-like activity [1]. Additionally, RAGE/SERT-IN-1 administered orally (60 mg/kg) and intravenously (IV) (10 mg/kg) shows favorable pharmacokinetic profiles in mice, with a half-life (T 1/2) of 5.55 and 3.46 hours, maximum concentration (C max) of 4935 and 51745 ng/mL, area under the curve (AUC 0-∞) of 24684 and 23653 ng/mL·h, clearance (CL) of 7.09 mL/min/kg, steady-state volume of distribution (V SS) of 1037 L/kg, and bioavailability (F) of 17.1% [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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