Product Details
| Product Name:
R306465 |
CAS No.:
604769-01-9 |
| Purity:
99.64% |
Supply Ability:
10g |
| Release date:
2025/07/25 |
Product Introduction
Bioactivity
| Name | R306465 |
| Description | R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies. |
| In vitro | b>METHODS: A2780 cells were treated with R306465 (0.1, 0.3, 1 μM, 24-48 h), and FACS analysis was performed to analyze whether the antiproliferative effect in A2780 cells was attributed to the induction of cell cycle arrest or cell death.
RESULTS: R306465 induced apoptosis of A2780 cells in a concentration-dependent manner and inhibited angiogenesis. [2] |
| In vivo | b>METHODS: R306465 (10-40 mpk, oral) was administered subcutaneously to nude mice bearing A2780, H460, and HCT116 cell models, and tumor growth in nude mice was observed.
RESULTS: R306465 inhibited tumor growth in the three nude mouse models. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5 mg/mL (12.09 mM), Sonication is recommended.
|
| Keywords | R306465 | HDAC1 | Apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Cysteamine hydrochloride | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | Valproic Acid | Curcumin | L-Ascorbic acid sodium salt | Alginic acid |
| Related Compound Libraries | Apoptosis Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Hematonosis Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$7.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2020-02-18 |
United States