(R)-(-)-α-Methylhistamine dihydrobromide NEW
| Price | Get Latest Price |
| Package | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-24 |
Product Details
| Product Name: (R)-(-)-α-Methylhistamine dihydrobromide | CAS No.: 868698-49-1 |
| Supply Ability: 10g | Release date: 2025/07/24 |
Product Introduction
Bioactivity
| Name | (R)-(-)-α-Methylhistamine dihydrobromide |
| Description | (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a dissociation constant (Kd) of 50.3 nM. |
| In vitro | (R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist with over 10 times the potency of histamine (HA). It exhibits weak affinities for H1 and H2 receptors, with pKi values of 4.8 and <3.5, respectively. The compound shows more than 1,000 times selectivity for H3-receptors compared to HA and over 200-fold selectivity over H4 receptors[1]. |
| In vivo | (R)-alpha-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[2].Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide reverses propofol‐induced memory retention[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | α-Methylhistamine Dihydrobromide | α-Methylhistamine | HistamineReceptor | Histamine Receptor | H3 Receptor | a-Methylhistamine Dihydrobromide | a-Methylhistamine | alpha-Methylhistamine Dihydrobromide | alpha-Methylhistamine | (R)()αMethylhistamine dihydrobromide | (R) ( ) α Methylhistamine dihydrobromide |
| Inhibitors Related | Chlorphenesin | Meclizine dihydrochloride | Mirtazapine | Lidocaine | Famotidine | Mebhydrolin napadisylate | Sodium butanoate | Amitriptyline hydrochloride | Nizatidine | Alginic acid | Trazodone hydrochloride | Mianserin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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