QL-X-138 NEW
| Price | $193 | $579 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-26 |
Product Details
| Product Name: QL-X-138 | CAS No.: 1469988-63-3 |
| Purity: 99.50% | Supply Ability: 10g |
| Release date: 2025/07/26 |
Product Introduction
Bioactivity
| Name | QL-X-138 |
| Description | QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK. The IC50 values of QL-X-138 are 9.4 nM for BTK, 107.4 nM for MNK1, 26 nM for MNK2, and 3.5 μM against Dengue 2. QL-X-138 is used in the study of B-cell malignancies and B-cell malignant tumors. |
| In vitro | QL-X-138 (0.5-5 μM; 24-72 h) arrests the progression of Ramos, OCI-AML-3, U937, and U2932 cells cycle in a dose-dependent manner[1]. QL-X-138 (0.5-5 μM; 8-72 h) induces apoptosis of Ramos, OCI-AML-3, U937 and U2932 cells in a time- and dose-dependent manner.[1] QL-X-138 (3-10000 nM; 4 h) blocks BTK- and MNK-mediated signaling in lymphoma and leukemia cells.[1] QL-X-138 (72 h) demonstrates anti-proliferative activity against lymphoma and leukemia cell lines, with GI50 values of 0.31, 1.2, 0.49, 1.4, 0.4, 0.23, 0.95, 1.2, 1.4, 0.23, 1.3, 0.93, 1, and 2.4 μM for TMD8, U2932, Ramos, OCI-AML3, SKM-1, NOMO-1, NB4, HEL, U937, NALM6, MEC-1, MEC-2, Hs 505.T, and REC-1 cells, respectively.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | VirusProtease | Virus Protease | QL-X-138 | QL-X138 | QLX138 | QL-X 138 | QL X 138 | MNK | Dengue Fever virus | BTK |
| Inhibitors Related | EIDD-1931 | Phenytoin sodium | Anthraquinone | Vorinostat | L-Lysine | 2-Phenylethanol | L-Lysine hydrochloride | (-)-Epicatechin gallate | PCL 016 | (-)-α-Pinene | 4-Phenylbutyric acid | Aminothiazole |
| Related Compound Libraries | Reprogramming Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Hematonosis Compound Library | Anti-Viral Compound Library | Anti-Infection Compound Library | MAPK Inhibitor Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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