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Postion:Product Catalog >Probucol Impurity 15
Probucol Impurity 15
  • Probucol Impurity 15
  • Probucol Impurity 15
  • Probucol Impurity 15
  • Probucol Impurity 15
  • Probucol Impurity 15

Probucol Impurity 15 NEW

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Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-17

Product Details

Product Name: Probucol Impurity 15 Min. Order: 10mg
Purity: 99%+ HPLC Supply Ability: 1000
Release date: 2025/07/17
Molecular formula: C15H24O4S

Probucol Impurity 15

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
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  • Product Information

  • Product Number: P063015

  • English Name: Probucol Impurity 15

  • English Alias: methyl 3,5-di-tert-butyl-4-hydroxybenzenesulfonate

  • CAS Number: None

  • Molecular Formula: C??H??O?S

  • Molecular Weight: 300.41

  • Advantages

  • As an impurity reference standard for probucol, this compound has the following advantages:

  • With a well-defined structure and good stability, it can be used to analyze the by-product formation mechanism of sulfonation and esterification reactions during probucol synthesis or storage, helping to optimize the process and reduce impurity generation.

  • Containing tert-butyl, hydroxyl, and sulfonate groups, it can provide a standard substance for the detection of impurities with similar structures in drugs, significantly improving the quantitative accuracy of detection methods such as HPLC and LC-MS.

  • It helps to study the influence of special functional groups on the stability and potential toxicity of impurities, providing a scientific basis for formulating reasonable impurity control strategies.

  • Applications

  • Drug Development: During the research and development of probucol and its formulations, it is used as an impurity reference standard to identify and quantitatively analyze Probucol Impurity 15, accurately evaluating the purity of APIs and formulations.

  • Quality Control: As a standard substance, it is used to verify the sensitivity and specificity of detection methods such as HPLC and LC-MS, ensuring that the content of this impurity during production meets pharmacopoeia and relevant regulatory requirements.

  • Stability Studies: Investigating the degradation behavior of this impurity under different environmental conditions such as light, high temperature, and high humidity, evaluating its impact on the stability of probucol formulations, and providing data support for determining reasonable storage conditions and shelf life.

  • Background Description

  • Probucol is a drug used to treat hypercholesterolemia, which works by reducing cholesterol and triglyceride levels. During its synthesis, due to the complex reaction steps involving multiple functional group transformations, if reaction conditions are not properly controlled or raw materials remain, impurities such as methyl 3,5-di-tert-butyl-4-hydroxybenzenesulfonate are likely to be generated. With the continuous improvement of drug quality standards, strict control of probucol impurities has become an important part of ensuring drug safety and effectiveness. Therefore, research on this impurity is of great significance.
  • Research Status

  • Currently, research on Probucol Impurity 15 mainly focuses on the following aspects:

  • Detection Method Optimization: Using advanced technologies such as ultra-high-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and high-resolution mass spectrometry (HRMS) to develop highly sensitive and selective detection methods for trace detection of this impurity.

  • Synthesis Process Improvement: Deeply studying the formation pathway of this impurity, and developing synthesis processes that reduce impurity generation by optimizing reaction conditions (such as reaction temperature, time, catalyst selection) and raw material ratios.

  • Toxicological Evaluation: Evaluating the potential toxicity of this impurity through in vitro cytotoxicity experiments and animal models, providing data support for scientifically formulating reasonable impurity limit standards.

  • Stability Studies: Systematically studying the stability of this impurity under the influence of different environmental factors, analyzing its impact on the quality of probucol formulations, and further improving the drug quality control system

This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com








Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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