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Postion:Product Catalog >API>Antibiotics>Pretomanid
Pretomanid
  • Pretomanid
  • Pretomanid
  • Pretomanid
  • Pretomanid
  • Pretomanid

Pretomanid NEW

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Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-06-18

Product Details

Product Name: Pretomanid CAS No.: 187235-37-6
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/06/18

Pretomanid

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WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

    • Product Number: P109000
      English Name: Pretomanid
      English Alias: (S)-2-nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
      CAS Number: 187235-37-6
      Molecular Formula: C??H??F?N?O?
      Molecular Weight: 359.26

    • Product Advantages

    • High purity and controllable crystal form:HPLC purity ≥99.5%, with crystal form consistency confirmed by XRD (X-ray diffraction), meeting the strict quality requirements of WHO and FDA for new drug APIs.

    • Outstanding stability:Purity decrease <1% after storage at 25°C/RH60% for 6 months, and degradation products <0.3% in high-temperature (60°C) accelerated tests, suitable for complex formulation processes and long-term storage.

    • Single chiral configuration:Defined (S)-configuration with optical purity ≥99.0% (determined by chiral HPLC), avoiding potential toxicity risks from the (R)-isomer and complying with ICH Q6A requirements for chiral drugs.


    • Applications

    • Research and development of new anti-tubercular drugs:As a novel nitroimidazole antibiotic, it is used for treating multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), exerting bactericidal effects by inhibiting Mycobacterium tuberculosis DNA synthesis.

    • Combination therapy regimens:Combined with bedaquiline and linezolid to form short-course chemotherapy regimens (e.g., the Nix-TB regimen), clinical trials show a cure rate of over 90% in a 6-month course.

    • Pharmacokinetic research:It has an oral bioavailability of approximately 80% and low plasma protein binding rate (<20%), facilitating distribution to infection foci and providing data support for clinical dosing optimization.


    • Background Description
      Pretomanid is a new anti-tubercular drug developed by TubercuLogix (USA), which received FDA accelerated approval in 2019 for combination therapy of adult MDR-TB. It has a unique mechanism of action, damaging mycobacterial DNA after activation by nitroreductase, with bactericidal activity against dormant bacteria. WHO global data shows approximately 500,000 new MDR-TB cases annually, with traditional therapies requiring long treatment courses (18-24 months) and low success rates (50-60%). The introduction of Pretomanid has significantly shortened treatment cycles and improved cure rates, making it a key drug listed in WHO’s core anti-tubercular drug inventory.

    • Research Status

    • Clinical research progress:Phase III clinical trials (NCT02371200) showed a sputum culture conversion rate of 89% in the Pretomanid combination treatment group at 6 months, significantly higher than the placebo group (28%). Long-term follow-up (5 years) showed a recurrence rate <5% with good safety (main adverse reactions: nausea, headache, incidence <15%).

    • Drug resistance mechanism research:Resistance to Pretomanid in M. tuberculosis is primarily associated with mutations in the ndh gene (encoding nitroreductase), with a mutation rate of 2-5%, and no widely resistant strains have been reported.

    • Synthesis process optimization:The latest process uses chiral phase-transfer catalysis technology with (S)-epichlorohydrin as the starting material, increasing the total yield to 45% (20% higher than early processes) while reducing waste discharge, in line with green chemistry principles.

    • Formulation development:Oral tablets (200mg/tablet) and lyophilized injections have been developed. The injection uses micronization technology to increase solubility (apparent solubility improved from 0.2mg/mL to 1.5mg/mL), suitable for patients with gastrointestinal absorption disorders.

NOTE!

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com


NEW IN STOCK!

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Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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