PR-104 NEW
| Price | $1310 | $1710 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: PR-104 | CAS No.: 851627-62-8 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | PR-104 |
| Description | PR-104 is a highly specific hypoxia-activated agent that cross-links DNA, enabling its application in various tumor xenograft models. Functioning as a pre-prodrug of nitrogen mustard, PR-104 undergoes efficient conversion to the dinitrobenzamide mustards alcohol form, known as PR-104A[1]. |
| In vitro | PR-104 demonstrates differential effects under various conditions in SiHa cells, showing enhanced inhibition of radiation-induced DNA single-strand breaks in hypoxic conditions compared to aerobic conditions at a concentration of 80 μM for 1 hour. At a higher concentration of 100 μM for the same duration, it triggers the phosphorylation of Ser139 on histone H2AX. Furthermore, with a dosage of 0.266 mmol/kg over 18 hours, PR-104 exhibits efficacy against hypoxic cells post-irradiation. Its effectiveness varies across cell lines, exhibiting a range in IC50 values from as low as 0.51 μmol/L in H460 cells to as high as 7.3 μmol/L in PC3 prostate cells. |
| In vivo | PR-104 (0.56 mmol/kg; i.v. or i.p.; 0-2 hours) increases the plasma area under the curve, while PR-104 (0.23 mmol/kg; i.p.; 100 days) demonstrates antitumor activity[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PR104 | PR 104 | PR-104 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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