Product Details
| Product Name:
Picrotoxinin |
CAS No.:
17617-45-7 |
| Purity:
98.07% |
Supply Ability:
10g |
| Release date:
2025/07/17 |
Product Introduction
Bioactivity
| Name | Picrotoxinin |
| Description | Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties. |
| In vitro | Picrotoxinin (1 nM-1 mM) dose-dependently inhibits the action of the GABAA receptor and inhibits etomidate, propofol, diazepam, thiopentone sodium, loreclezole and allopregnanolone with IC50s of 0.55 μM, 0.49 μM, 0.35 μM, 0.50 μM, 0.14 μM and 0.44 μM in the presence of EC5 GABA, respectively[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90.0 mg/mL (307.9 mM), Sonication is recommended.
|
| Keywords | Picrotoxinin | GABAReceptor | GABAA | GABA Receptor | Chloridechannel | chloride channel | Chloride channel |
| Inhibitors Related | Valproic acid sodium salt | DL-Menthol | Urethane | p-Hydroxybenzaldehyde | Penicillin G sodium salt | Valproic Acid | Halothane | Chlorothymol | Riluzole | Fenamic acid | (-)-α-Pinene | Methionine |
| Related Compound Libraries | Terpene Natural Product Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Ion Channel Targeted Library | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States