Picropodophyllotoxin NEW
| Price | $32 | $74 | $96 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-05 |
Product Details
| Product Name: Picropodophyllotoxin | CAS No.: 17434-18-3 |
| Purity: 99.57% | Supply Ability: 10g |
| Release date: 2025/07/05 |
Product Introduction
Bioactivity
| Name | Picropodophyllotoxin |
| Description | Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (108.59 mM), Sonication is recommended. |
| Keywords | Picropodophyllotoxin | IGF-1R | IGF1R | AXL-1717 | AXL1717 |
| Inhibitors Related | Insulin (human) | Urolithin C | Indirubin Derivative E804 | ALK-IN-1 | I-OMe-Tyrphostin AG 538 | Ceritinib | GSK1904529A | Brigatinib | HNMPA | PD173074 | Tyrphostin AG 538 | Linsitinib |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Miao medicine Compound Library | Anti-Aging Compound Library | The Yao nationality medicine Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-COVID-19 Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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