
Phthalazinone pyrazole NEW
Price | $58 | $88 | $148 |
Package | 1mg | 2mg | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2025-07-25 |
Product Details
Product Name: Phthalazinone pyrazole | CAS No.: 880487-62-7 |
Purity: 98.22% | Supply Ability: 10g |
Release date: 2025/07/25 |
Product Introduction
Bioactivity
Name | Phthalazinone pyrazole |
Description | Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity. |
In vitro | Phthalazinone pyrazole potently inhibited the activity of Aurora A kinase with an IC50 of 31 nM. It showed no inhibitory effect on Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibited the proliferation of HCT116, Colo205, and MCF-7 cells with IC50 values of 7.8, 2.9, and 1.6 μM, respectively [1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Solubility Information | DMSO : Slightly soluble |
Keywords | tumor growth | Phthalazinone pyrazole | oral | Inhibitor | inhibit | human embryonic stem cells | HLCs | hepatocyte-like cell | epithelial-mesenchymal transition | EMT | AuroraKinase | Aurora-A kinase | Aurora Kinase | Aurora A | apoptosis |
Inhibitors Related | Palmatine chloride | MK-8745 | SC-514 | Barasertib-HQPA | MBM-55S | SP600125 | KW-2449 | Palmatine | TAK-901 | Alisertib | Tozasertib | TCS7010 |
Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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