Product Details
| Product Name:
Pentabromopseudilin |
CAS No.:
10245-81-5 |
| Supply Ability:
10g |
Release date:
2025/04/29 |
Product Introduction
Bioactivity
| Name | Pentabromopseudilin |
| Description | Pentabromopseudilin (PBrP), a marine antibiotic derived from Pseudomonas bromoutilis and Alteromonas luteoviolaceus, demonstrates antimicrobial, antitumor, and phytotoxic properties. It acts as a reversible, allosteric inhibitor of myosin Va (MyoVa) and robustly inhibits transforming growth factor-β (TGF-β) activity. PBrP is utilized in researching fibrotic diseases and cancer [1]. |
| In vitro | Pentabromopseudilin (PBrP) at concentrations of 0.01-1 μM for 6 hours inhibited TGF-β-induced phosphorylation and nuclear translocation of Smad proteins [1]. Additionally, at 0.5 μM for 6 hours, PBrP suppressed the transcriptional response stimulated by TGF-β [1]. Furthermore, PBrP across a range of 0-1 μM for 6 hours impeded TGF-β-induced epithelial-mesenchymal transition (EMT) in A549 cells [1]. At a specific dose of 0.2 μM for 20 hours, PBrP obstructed cell migration prompted by TGF-β [1]. PBrP at 0.01-1 μM for 6 hours blocked TGF-β signaling by enhancing the degradation of TβRII [1]. At a concentration of 0.5μM and at time intervals of 0, 1, and 3 hours, PBrP disrupted TGF-β signaling by promoting TβRII degradation through caveolae-dependent endocytosis [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
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