PD-L1-IN-2 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-16 |
Product Details
| Product Name: PD-L1-IN-2 | CAS No.: 2894733-91-4 |
| Supply Ability: 10g | Release date: 2025/05/16 |
Product Introduction
Bioactivity
| Name | PD-L1-IN-2 |
| Description | PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity. In vivo studies indicate that it suppresses PD-L1 expression and amplifies tumor-infiltrating T-cell response, thus exerting anticancer effects. This compound is particularly utilized in the investigation of colorectal cancer [1]. |
| In vitro | PD-L1-IN-2 (compound 11c) has an IC50 value of 31.7 μM against RKO cells [1]. In concentrations of 0-10 μM and over 0-24 hours, PD-L1-IN-2 inhibits PD-L1 expression in RKO cells dose- and time-dependently [1]. PD-L1-IN-2 also enhances PD-L1 protein turnover, as shown by an accelerated PD-L1 turnover rate in treated cells compared to untreated cells in a CHX pulse-chase assay [1]. |
| In vivo | Administered intraperitoneally at 25/50 mg/kg once daily for 16 days, PD-L1-IN-2 (compound 11c) resulted in tumor size reduction, with the 50 mg/kg group showing a 45% inhibition rate and significantly lower average tumor weight compared to the PBS group [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | PD-L1 | PDL1 | PD1/PDL1 | PD-1 | PD1 |
| Inhibitors Related | LSD1-IN-24 | PD-1/PD-L1-IN-9 | Sulfamethoxypyridazine | BMS-202 | PD-1-IN-22 | BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride | IMMH 010 maleate | Camrelizumab | LSD1-IN-27 | BMS-1 | Anti-Mouse PD-1 Antibody (RMP1-14) | PD-L1-IN-3 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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