Product Details
| Product Name:
PB1 |
CAS No.:
188714-28-5 |
| Supply Ability:
10g |
Release date:
2025/07/20 |
Product Introduction
Bioactivity
| Name | PB1 |
| Description | PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven instrumental in the study of neuroprotective properties[1][2][3]. |
| In vitro | PB1 significantly enhances the activation of the BDNF effector ERK1/2 and supports RGC survival [1]. |
| In vivo | PB1 (150 μM; intraocular injection; 1 week) attenuates the loss of both retinal ganglion cells (RGC) soma and axons in experimental glaucoma[1]. PB1 single dose limits the biological activity in vivo. PB1 (0.001~100 μM; 72 hours) effectively rescues acutely axotomized retinal ganglion cells[1][2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (337.71 mM), Sonication is recommended.
|
| Keywords | PB1 | PB 1 | PB-1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States