para-amino-Blebbistatin NEW
| Price | Get Latest Price | |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-26 |
Product Details
| Product Name: para-amino-Blebbistatin | CAS No.: 2097734-03-5 |
| Supply Ability: 10g | Release date: 2025/07/26 |
Product Introduction
Bioactivity
| Name | para-amino-Blebbistatin |
| Description | para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.5,6 The addition of a 4'-amino group increases its water solubility, decreases the inherent fluorescence, stabilizes the molecule to circumvent its degradation by prolonged blue light exposure, and decreases its phototoxicity while retaining the in vitro and in vivo activity of blebbistatin.7 para-amino-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF:PBS (pH 7.2) (1:1) : 0.5 mg/mL (1.63 mM), Sonication is recommended. DMF : 20 mg/mL (65.07 mM), Sonication is recommended. DMSO : 12.5 mg/mL (40.67 mM), Sonication is recommended. |
| Keywords | paraaminoBlebbistatin | para amino Blebbistatin | para-amino-Blebbistatin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| $89.00/1mg |
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TargetMol Chemicals Inc.
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TargetMol Chemicals Inc.
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| $75.00/1kg |
Hebei Zhuanglai Chemical Trading Co.,Ltd
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2024-06-07 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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