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Postion:Product Catalog >Ozanimod Impurity 41
Ozanimod Impurity 41
  • Ozanimod Impurity 41
  • Ozanimod Impurity 41
  • Ozanimod Impurity 41
  • Ozanimod Impurity 41
  • Ozanimod Impurity 41

Ozanimod Impurity 41 NEW

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Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-18

Product Details

Product Name: Ozanimod Impurity 41 CAS No.: 1306763-41-6
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/18
Molecular formula: C23H36N2O3Si

Ozanimod Impurity 41

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
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  • Product Information

  • Product Number: O036041

  • English Name: Ozanimod Impurity 41

  • English Alias: (R)-tert-butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate

  • CAS Number: 1306763-41-6

  • Molecular Formula: C??H??N?O?Si

  • Molecular Weight: 416.63

  • Advantages

  • As an impurity of Ozanimod, this compound has the following advantages:

  • Well-defined and distinct structure: Contains tert-butyl carbamate, TBS ether, and 4-cyanoindane moieties, differing from ozanimod intermediates by retained protecting groups. It can be accurately identified via HPLC and GC-MS as a specific marker for impurity detection;

  • High stability and traceability: Synergistic effects of silyl ether and carbamate ensure stability under non-acidic conditions. As a by-product of incomplete deprotection in ozanimod synthesis, it directly reflects deprotection efficiency, improving process tracing accuracy;

  • High detection sensitivity: Unique retention behavior from cyano polarity and silyl hydrophobicity, combined with indane UV absorption (240-260nm), enables trace analysis via HPLC-UV or GC-MS, compatible with silyl-protected amine detection systems.

  • Applications

  • Pharmaceutical quality control: Used as an impurity reference standard to quantify Ozanimod Impurity 41 in API production, ensuring residual protected impurities meet quality standards post-deprotection;

  • Synthesis optimization: Optimizing TBS/carbamate deprotection conditions (e.g., acid concentration, time) by monitoring impurity levels to enhance intermediate purity and reduce downstream interference;

  • Intermediate quality assessment: Evaluating chiral intermediate purity in ozanimod synthesis to support efficiency of subsequent cyclization and amination reactions.

  • Background Description

  • Ozanimod, a sphingosine-1-phosphate receptor modulator for multiple sclerosis, requires multi-step protecting group manipulations (e.g., TBS for hydroxyl, Boc for amine). Incomplete deprotection may leave bis-protected derivatives like Ozanimod Impurity 41. Such impurities can disrupt reaction specificity, making their control critical for ozanimod quality assurance.
  • Research Status

  • Current research focuses on:

  • Analytical method development: Validating UPLC-DAD assays with optimized mobile phases for baseline separation of impurity and target intermediate, achieving 0.5 ppm detection limits;

  • Deprotection kinetics: Studying impurity degradation under varying acid conditions to clarify factors governing synchronous TBS/Boc removal;

  • Chiral purity validation: Developing chiral HPLC methods to confirm stereochemical consistency with ozanimod, ensuring no enantiomeric interference;

  • Scale-up process control: Implementing impurity monitoring in kg-scale production to optimize deprotection parameters for consistent quality.

This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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