Oxamflatin NEW
| Price | $61 | $186 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: Oxamflatin | CAS No.: 151720-43-3 |
| Purity: 98.25% | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | Oxamflatin |
| Description | Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor characterized by high potency (IC50 = 15.7 nM) and the presence of an alkyne group capable of undergoing azide-alkyne cycloaddition reactions (CuAAc). |
| In vitro | Methods: HeLa cells were cultured for 24 hours, and 1 mg/ml of Oxamflatin (Metacept-3) was added to the cultures at 0 hours. After the indicated incubation times, cells were harvested and their isolated nuclei were analyzed by flow cytometry; the distribution of cells in the cell cycle was determined using ModFit LT software. Results: Oxamflatin caused HeLa cells to have an elongated cell shape with filamentous processes and cell cycle arrest in the G1 phase. [1] |
| In vivo | Methods: Oxamflatin (Metacept-3) (8±50 mg/kg, intraperitoneal injection) was used in mice with B16 melanoma cell tumor xenografts at days 1, 3, 5, 7, 9, and 11 after inoculation. The increase in lifespan (ILS) of mice transplanted with B16 murine melanoma tumors after treatment with oxamˉatin was measured, and the number of days of survival was calculated and the ILS% was calculated. Results: Six injections of oxamflatin at a dose of 20 mg/kg each time significantly increased the number of days of survival of mice (38% of ILS); the ILS of mice treated with 50 mg/kg of oxamflatin was calculated to be over 67%, and one mouse survived for more than 60 days after tumor inoculation. No side effects such as weight loss were observed, at least until this dose. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 125 mg/mL (365.1 mM), Sonication is recommended. |
| Keywords | Oxamflatin | HDAC |
| Inhibitors Related | Panobinostat | Theophylline monohydrate | Valproic acid sodium salt | Sodium 4-phenylbutyrate | Acefylline | Vorinostat | Valproic Acid | Curcumin | Parthenolide | 4-Phenylbutyric acid | Theophylline | Methyl L-histidinate dihydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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