OT-82 NEW
| Price | $299 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: OT-82 | CAS No.: 1800487-55-1 |
| Purity: 98.91% | Supply Ability: 10g |
| Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | OT-82 |
| Description | OT-82 is a potent, selective, and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). |
| In vitro | METHODS: OT-82 (0.001-10 μM) was used to treat human cell lines derived from HP and non-HP cancers, and the IC50 values ??were determined. RESULTS: The average IC50 of OT-82 was significantly higher in non-HP cancer cells compared with HP cancer cells (13.03±2.94 nM vs 2.89±0.47 nM; p < 0.008). [1] METHODS: MV4-11 cells were treated with OT-82 (0.001-10 nM), and the changes in NAD were observed for 24 hours, and the changes in ATP were observed for 24 hours and 48 hours. RESULTS: OT-82 treatment resulted in a dose-dependent decrease in NAD and ATP concentrations in MV4-11 cells. OT-82 treatment of MV4-11 cells in vitro for 48 hours resulted in caspase-3 activation, an increase in the proportion of cells with sub-G1 DNA content, and mitochondrial membrane depolarization. OT-82 induced apoptosis and cell death by inhibiting NAMPT, leading to NAD and ATP depletion. [1] |
| In vivo | METHODS: OT-82 (25 or 50 mg/kg) was administered orally 6 days per week for 3 weeks. The therapeutic efficacy of OT-82 was tested in vivo using subcutaneous (SC) and systemic mouse xenograft models of HP malignancies. RESULTS: OT-82 caused a dose-dependent inhibition of SC growth of human AML-derived MV4-11 cells; the 25 mg/kg dose resulted in a 3-fold reduction in mean tumor volume at day 17 of treatment, while higher doses resulted in complete eradication of tumors within 10 days of treatment initiation. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (188.47 mM), Sonication is recommended. |
| Keywords | OT-82 | Nampt | NAMPT |
| Inhibitors Related | GNE-617 | Nampt-IN-5 | LB-60-OF61 | Nampt activator-2 | SBI-797812 | Nampt-IN-1 | KPT9274 | CHS-828 | Nampt activator-1 | (E)-Daporinad | STF-118804 | Daporinad hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1980.00/50mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2025-07-24 | |
| $195.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-07-21 | |
| $2.00/25KG |
VIP7Y
|
Jinan Finer Chemical Co., Ltd
|
2022-08-23 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY