OSMI-2 NEW
| Price | $1970 | $2580 | $3400 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: OSMI-2 | CAS No.: 2260542-60-5 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | OSMI-2 |
| Description | OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT). |
| In vitro | In ?HCT116 cells,OSMI-2 ?treatment reduces O-GlcNAc levels at short treatment times (<8h).?However, O-GlcNAc levels begins to recover at longer treatment times with OSMI-2.?A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-2 ?is observed.?Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-2 on cell growth in culture over 96h is also monitored.?Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.?A time course performed with 20 μM OSMI-2 shows reciprocal changes in the abundance of OGT and OGA, with a particularly large increase in OGT;?this may explain the recovery in O-GlcNAc levels with OSMI-2.?At 24h where O-GlcNAc levels fully recovered[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | OSMI2 | OSMI 2 | OSMI-2 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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